Logitech Signature M650: Quiet wireless mouse for big, small or left-handers

Many mice offer very basic features – left click, right click, scroll wheel, and more. Others boast a set of programmable buttons, premium sensors, USB-C charging, and other features for power users. But what if you don’t need this extreme level of functionality, but you also don’t want something cheap and simple?

Launched last week, the Logitech Signature M650 Wireless Mouse is a mid-range device that supports Windows, macOS, Linux, Chrome OS, iPadOS, and Android. It doesn’t have the most advanced features, but it’s not basic either. And, skipping some add-ons like a few Bluetooth profiles, the mouse can maintain an affordable $40 price tag.

Logitech’s latest wireless mouse also comes in three different versions: a standard size, a large size, and a left-handed large version, offering something for everyone unless you have a smaller left hand.

Different hands and sizes

Logitech makes it easy to determine which version is best for you. Those with small to medium sized hands up to 7.5″should get the standard M650, while those with arms longer than 7.5″should opt for the M650 L.

If you have tiny hands and want a similar wireless mouse, there are smaller options like the Razer Pro Click Mini (3.9×2.5×1.3 inches, 3.1 ounces with a single battery).

The medium size version measures 4.22 x 2.43 x 1.49 inches and 3.57 ounces. This makes it slightly smaller in length and width (but noticeably heavier) than the Logitech Pop Mouse (4.5 × 2.6 × 1.4 inches and 2.9 ounces), another Logitech MSRP wireless mouse 40 dollars.

The large M650 (4.65×2.58×1.63in, 3.92oz) is 10.19% longer and 9.8% heavier than the standard size version I tested. That’s quite a lot for a wireless mouse for productivity.

That’s even bigger than the Corsair Katar Pro Wireless Gaming Mouse (MSRP $40), which measures 4.56 x 2.53 x 1.49 inches and weighs 3.39 ounces. However, there are bulkier wireless mice, including those from Logitech. The similarly shaped and lower priced Logitech M510 (4.72×2.56×1.6 inches, 4.55 oz) is so heavy it feels awkward to use.

There is a left-handed version of the M650 – the side buttons are on the right side of the mouse – but it’s only available in the large size. Left-handed wireless mice are hard to come by – there’s the $100 Logitech G903, as well as less traditional mice like ergonomic mice and the Microsoft Surface Arc. But for a mainstream performance-focused wireless mouse, this left-handed option is a rare treat.

Having so many options makes it easier for people to find the right option, especially if they don’t already have a mouse form factor preference. There are mice that take size customization to the extreme, but the M650 should provide enough room for most people.

According to the Logitech chart, I have a medium sized hand. My typical claw-like grip with the M650 felt good, as my thumb, ring finger, and pinky held firmly to the textured sides of the mouse. Meanwhile, my thumb could move up and activate both side buttons almost effortlessly. My index and middle fingers fit naturally into the downward slope of the main buttons, but holding them in my preferred position for quick taps required more effort to keep my hand from sliding down.

I was not inclined to use my additional grip type, the palm, on the M650 due to its shorter length. My index and middle fingers dipped significantly over the top edge when gripped, making it difficult to navigate left and right clicks. But the mouse’s large hump helped with comfort.